New imaging technique sheds light on adult zebrafish brain

By: Krishna Ramanujan,  Cornell Chronicle
Tue, 04/28/2020

Cornell scientists have developed a new technique for imaging a zebrafish’s brain at all stages of its development, which could have implications for the study of human brain disorders, including autism.

Zebrafish are translucent when young, making them good models for live imaging, but they become opaque with age, which has prevented researchers from seeing into a live adult brain.

Now, an interdisciplinary team from Cornell Neurotech has developed a microscopy tool to use with adult zebrafish engineered with calcium sensors that light up to reveal when neurons are activated.